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Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research

Shuyang Sun,Zhiyuan Zhang

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 104-110 doi: 10.1007/s11684-016-0432-4

Abstract: Sophisticated preclinical models that fully represent intra- and inter-tumoral heterogeneity are requiredPatient-derived xenograft (PDX) models generated from human tumor samples that can retain the histologicalSpecifically, genetically well-defined PDX models can be applied to accelerate targeted antitumor drugthis paper, we discuss the establishment, characterization, and preclinical applications of the PDX modelsthe translational value of this well-annotated PDX panel in the development of co-clinical trials for patient

Keywords： patient-derived xenograft models     personalized medicine     co-clinical trial     patient stratification     oral    

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Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 290-303 doi: 10.1007/s11684-022-0956-8

Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide. It is urgent to develop new drugs to improve the prognosis of ESCC patients. Here, we found benzydamine, a locally acting non-steroidal anti-inflammatory drug, had potent cytotoxic effect on ESCC cells. Benzydamine could suppress ESCC proliferation in vivo and in vitro. In terms of mechanism, CDK2 was identified as a target of benzydamine by molecular docking, pull-down assay and in vitro kinase assay. Specifically, benzydamine inhibited the growth of ESCC cells by inhibiting CDK2 activity and affecting downstream phosphorylation of MCM2, c-Myc and Rb, resulting in cell cycle arrest. Our study illustrates that benzydamine inhibits the growth of ESCC cells by downregulating the CDK2 pathway.

Keywords： benzydamine     cyclin-dependent kinase 2     patient-derived xenograft     esophageal squamous cell carcinoma    

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Prediction of Driver Gene Matching in Lung Cancer NOG/PDX Models Based on Artificial Intelligence Article

Yayi He, Haoyue Guo, Li Diao, Yu Chen, Junjie Zhu, Hiran C. Fernando, Diego Gonzalez Rivas, Hui Qi, Chunlei Dai, Xuzhen Tang, Jun Zhu, Jiawei Dai, Kan He, Dan Chan, Yang Yang

Engineering 2022, Volume 15, Issue 8,   Pages 102-114 doi: 10.1016/j.eng.2021.06.017

Abstract:

Patient-derived tumor xenografts (PDXs) are a powerful tool for drug discovery and screening in cancerHere, we established PDX models from 53 lung cancer patients with a genotype matching rate of 79.2% (Finally, the performance of all models was evaluated by the accuracy, area under the receiver operatingTwo multivariable LR models revealed that age, number of driver gene mutations, epidermal growth factorand offer a general approach for building predictive models.

Keywords： Machine learning     Patient-derived tumor xenografts     NOG mice    

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Tumor-Specific CircRNA-Derived Antigen Peptide Identification for Hepatobiliary Tumors Article

Wenwen Wang, Lili Ma, Zheng Xing, Tinggan Yuan, Jinxia Bao, Yanjing Zhu, Xiaofang Zhao, Yan Zhao, Yali Zong, Yani Zhang, Siyun Shen, Xinyao Qiu, Shuai Yang, Hongyang Wang, Dong Gao, Peng Wang, Lei Chen

Engineering 2023, Volume 22, Issue 3,   Pages 159-170 doi: 10.1016/j.eng.2022.06.008

Abstract: CircRNA-derived tumor-specific peptides presented by the HLA-ABC molecules stimulated cluster of differentiationCytotoxic T cell activity targeting the organoids, induced by the immunogenic circRNA-derived peptides

Keywords： Tumor antigen     Patient-derived hepatobiliary tumor organoid     Circular RNA     Mass-spectrometry-based immunopeptidomics    

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Effect of atorvastatin on tumor growth and metastasis in a breast cancer cell xenograft model and its

Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 443-446 doi: 10.1007/s11684-009-0079-5

Abstract: evaluate the effects and the possible mechanisms of atorvastatin on tumor growth and metastasis in a xenograftTwenty-four female athymic BALB/C mice with MDA-MB-435 xenograft tumors were randomly assigned to threetreatment groups began to be administered with atorvastatin (10 or 20 mg/kg per day) when the xenograftAtorvastatin suppressed xenograft tumor growth and metastasis both in the low-dose and the high-dose

Keywords： atorvastatin     xenograft tumor     metastasis     CYP2J2    

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Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report

Haiyan He, Ran An, Jian Hou, Weijun Fu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 284-286 doi: 10.1007/s11684-017-0514-y

Abstract: In this report, we present a rare side effect, rhabdomyolysis, in a 68-year-old female APL patient who

Keywords： arsenic trioxide     APL     rhabdomyolysis    

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An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

Xiang Du

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 506-509 doi: 10.1007/s11684-013-0294-y

Abstract:

This study aimed to investigate patient dose in diagnostic screen-film radiographic examinations in

Keywords： radiation dosage     radiology     radiation protection     radiography/statistics & numerical data    

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Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: To identify the potential pathogenic mutations in a Chinese patient with CF, we conducted Sanger sequencingon the genomic DNA of the patient and his parents and detected all 27 coding exons of CFTR andThe patient is a compound heterozygote of c.2909G>A, p.Gly970Asp in exon 18 and c.1210-3C>G in cisOverall, c.1210-3C>G, the newly identified pathogenic mutation in our patient, in combination with T5Moreover, this patient carries a p.Gly970Asp mutation, thus confirming the high-frequency of this mutation

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibits the activation of immune cells through the interaction with its ligand CD24 on tumor cells. Here, by analyzing public databases containing 64 517 patients of 33 cancer types, we found that the expression of Siglec10 was altered in 18 types of cancers and was associated with the clinical outcomes of 11 cancer types. In particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRC) and was inversely associated with the prognosis of the patients. In 131 KIRC patients of our settings, Siglec10 was elevated in the tumor tissues of 83 (63.4%) patients compared with that in their counterpart normal kidney tissues. Moreover, higher level of Siglec10 was associated with advanced disease (stages III and IV) and worse prognosis. Silencing of CD24 in KIRC cells significantly increased the number of Siglec10-expressing macrophages phagocytosing KIRC cells. In addition, luciferase activity assays suggested that Siglec10 was a potential target of the transcription factors c-FOS and GATA1, which were identified by data mining. These results demonstrate that Siglec10 may have important oncogenic functions in KIRC, and represents a novel target for the development of immunotherapies.

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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Xingnao Kaiqiao acupuncture combined with Angong Niuhuang Wan for a patient under persistent vegetative

Hujie Song, Xiao Chen, Yalan Yu, Ling Zhang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 334-339 doi: 10.1007/s11684-017-0539-2

Abstract: Our patient is a male and 5 years and 3 months of age.

Keywords： PVS     stubborn disease     Xingnao Kaiqiao     Angong Niuhuang Wan     TCM     acupuncture    

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Ventricular tachycardia in a disseminated MDR-TB patient: a case report and brief review of literature

Hui Li,Ran Li,Jiuxin Qu,Xiaomin Yu,Zhixin Cao,Yingmei Liu,Bin Cao

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 259-263 doi: 10.1007/s11684-014-0321-7

Abstract:

Although significant breakthroughs have been achieved in tuberculosis management, we still encounter numerous difficulties in diagnosis and treatment of the disease. Additionally, a new challenge, multidrug-resistant tuberculosis (MDR-TB) with unspecific clinical presentation, often results in delayed diagnosis. In this paper, we reported a case of disseminated tuberculosis with rare presentation of ventricular fibrillation, which proved resistant to both isoniazid and rifampicin. A review of literature showed that ventricular fibrillation or tachycardia in tuberculosis patients with pericarditis or myocarditis has been sporadically reported in the past, but none has been conducted involving patients with MDR-TB infections.

Keywords： tuberculosis     MDR-TB     ventricular tachycardia    

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A review on different theoretical models of electrocaloric effect for refrigeration

Frontiers in Energy 2023, Volume 17, Issue 4,   Pages 478-503 doi: 10.1007/s11708-023-0884-6

Abstract: This paper reviews the electrocaloric effect of ferroelectric materials based on different theoretical models

Keywords： electrocaloric effect     effective Hamiltonian     phase-field modeling     different theoretical models    

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Tuning porosity of coal-derived activated carbons for CO2 adsorption

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 9,   Pages 1345-1354 doi: 10.1007/s11705-022-2155-1

Abstract: A simple method was developed to tune the porosity of coal-derived activated carbons, which provided

Keywords： coal-derived activated carbons     porosity     CO2 adsorption     molecular dynamics    

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Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis B: a case report

Lei Li,Yimei Liu,Tiancheng Luo,Jian Zhou,Yingyong Hou,Xizhong Shen,Jiyao Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 250-253 doi: 10.1007/s11684-014-0333-3

Abstract:

The clinical data of a patient with acute-on-chronic liver failure were analyzed retrospectively.The patient has suffered from hepatitis B for 30 years.The patient also presented hepatocellular carcinoma.The patient recovered uneventfully and was discharged after surgery.

Keywords： acute-on-chronic liver failure     submassive necrosis     viral hepatitis B     esophageal variceal bleeding     liver transplantation    

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Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 534-548 doi: 10.1007/s11684-022-0953-y

Abstract: Human menstrual blood-derived stem cells (MenSCs) have shown therapeutic effect in acute lung injury

Keywords： autoimmune hepatitis (AIH)     concanavalin A (Con A)     human menstrual blood-derived stem cells (MenSCs)    

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Title Author Date Type Operation

Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research

Shuyang Sun,Zhiyuan Zhang

Journal Article

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Journal Article

Prediction of Driver Gene Matching in Lung Cancer NOG/PDX Models Based on Artificial Intelligence

Yayi He, Haoyue Guo, Li Diao, Yu Chen, Junjie Zhu, Hiran C. Fernando, Diego Gonzalez Rivas, Hui Qi, Chunlei Dai, Xuzhen Tang, Jun Zhu, Jiawei Dai, Kan He, Dan Chan, Yang Yang

Journal Article

Tumor-Specific CircRNA-Derived Antigen Peptide Identification for Hepatobiliary Tumors

Wenwen Wang, Lili Ma, Zheng Xing, Tinggan Yuan, Jinxia Bao, Yanjing Zhu, Xiaofang Zhao, Yan Zhao, Yali Zong, Yani Zhang, Siyun Shen, Xinyao Qiu, Shuai Yang, Hongyang Wang, Dong Gao, Peng Wang, Lei Chen

Journal Article

Effect of atorvastatin on tumor growth and metastasis in a breast cancer cell xenograft model and its

Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,

Journal Article

Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report

Haiyan He, Ran An, Jian Hou, Weijun Fu

Journal Article

An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

Xiang Du

Journal Article

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

Xingnao Kaiqiao acupuncture combined with Angong Niuhuang Wan for a patient under persistent vegetative

Hujie Song, Xiao Chen, Yalan Yu, Ling Zhang

Journal Article

Ventricular tachycardia in a disseminated MDR-TB patient: a case report and brief review of literature

Hui Li,Ran Li,Jiuxin Qu,Xiaomin Yu,Zhixin Cao,Yingmei Liu,Bin Cao

Journal Article

A review on different theoretical models of electrocaloric effect for refrigeration

Journal Article

Tuning porosity of coal-derived activated carbons for CO2 adsorption

Journal Article

Comprehensive treatment of acute-on-chronic liver failure in a patient with hepatitis B: a case report

Lei Li,Yimei Liu,Tiancheng Luo,Jian Zhou,Yingyong Hou,Xizhong Shen,Jiyao Wang

Journal Article

Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway

Journal Article